The UCLA Cardiac Arrhythmia Center has a strong focus on clinical and translational research. The center has approximately 20 clinical trials in progress or development. Many of our trials are physician initiated with a strong desire to find new and innovative methods and treatments for our patients. We also participate in NIH and industry sponsored trials that support our clinic's vision and mission. Our trials include a focus on arrhythmia management such as cardiac devices, medications and procedures such as cardioversion, ablations, and lead extractions.
There are approximately 200 scientific journal articles published by our center on PubMed. The articles are posted on PubMed that comprises of more than 25 million citations for biomedical literature.
Below are listed our current trials that are actively enrolling patients. Other trials can be located on the clinicaltrials.gov website.
Title: Multicenter Automatic Defibrillator Implantation Trial - Chemotherapy Induced Cardiomyopathy (MADIT-CHIC)
Study Aim: To determine if CRT-D in patients with chemotherapy induced cardiomyopathy will improve the patient's LVEF.
Principal Investigator: Eric Yang, M.D, FACC
Co-Investigators: Noel Boyle M.D, PhD; Shelly Cote, RN, NP; Julie M. Sorg, RN, MSN
Title: Catheter Ablation vs. Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) Trial
Study Aim: To determine which treatment for atrial fibrillation (medication or ablation) is best for the long-term health of patients.
Principal Investigator: Eric Buch, M.D, MS
Co-Investigators: Kalyanam Shivkumar, M.D,. Ph.D; Shelly Cote, RN, NP; Julie M. Sorg, RN, MSN
Title: Mechanism Behind teh Benefit of Neuraxial Modulation in Patients with Ventricular Arrhythmias
Study Aim: To examine how the nerves of the heart impact abnormal heart rhythms.
Principal Investigator: Marmar Vaseghi, M.D, PhD
Co-Investigators: Kalyanam Shivkumar, M.D, PhD; Jason Bradfield, M.D; Shelly Cote, RN, NP; Julie M. Sorg, RN, MSN
Title: Electrophysiological Effects of Neural Remodeling of the Ventricle
Study Aim: To examine the heart's electrical behavior as it relates to the origin of fast and dangerous heartbeats in the ventricles.
Principal Investigator: Kalyanam Shivkumar, M.D, Ph.D
Co-Investigators: Aman Mahajan, M.D., Ph.D; Marmar Vaseghi, M.D.; Shelly Cote, RN, NP
Title: Localization of Focal Activity Using the Cardiac Isochrone Positioning System (CIPS)
Study Aim: To test the accuracy of CIPS to localize the PVCs or Ventricular Tachycardia (VT) in the heart.
Principal Investigator: Noel Boyle, MD, Ph.D
Co-Investigators: Peter Van Dam, PhD, Micheal Laks, MD, Julie M. Sorg, RN, MSN, Shelly Cote, RN, NP